Molecular modelling and cytotoxicity of substituted anthraquinonesas inhibitors of human telomerase

Cairns, D. and Michalitsi, E. and Jenkins, T.C. and Mackay, S.P. (2002) Molecular modelling and cytotoxicity of substituted anthraquinonesas inhibitors of human telomerase. Bioorganic and Medicinal Chemistry Letters, 10. pp. 803-807. ISSN 0960-894X (https://doi.org/10.1016/S0968-0896(01)00337-6)

Abstract

Molecular modelling has been carried out for a number of amine-functionalised anthraquinone derivatives to determine their extent of binding to G-tetraplex DNA and their ability to inhibit the enzymes telomerase and Taq polymerase. The results are compared to data obtained from a modified TRAP assay and show good correlation between the two methods. The findings suggest that anthraquinone derivatives of this type inhibit telomerase by stabilisation of four-stranded tetraplex structures associated with guanine-rich telomeric DNA regions.

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• Item metadata

  Item type:	Article
  ID code:	37878
  Dates:	Date Event 2002 Published
  Subjects:	Medicine > Pharmacy and materia medica
  Department:	Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
  Depositing user:	Pure Administrator
  Date deposited:	24 Feb 2012 15:16
  Last modified:	08 Apr 2024 16:27
  URI:	https://strathprints.strath.ac.uk/id/eprint/37878