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Metabolomic profiling of Drosophila using liquid chromatography Fourier transform mass spectrometry

Kamleh, M.A. and Watson, D.G. and Hobani, Y. and Dow, J.A.T. (2008) Metabolomic profiling of Drosophila using liquid chromatography Fourier transform mass spectrometry. FEBS Letters, 582 (19). pp. 2916-2922. ISSN 0014-5793

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Abstract

Hydrophilic interaction chromatography (HILIC) interfaced with an Orbitrap Fourier transform mass spectrometer (FT-MS) was used to carry out metabolomic profiling of the classical Drosophila mutation, rosy (ry). This gene encodes a xanthine oxidase/dehydrogenase. In addition to validating the technology by detecting the same changes in xanthine, hypoxanthine, urate and allantoin that have been reported classically, completely unsuspected changes were detected in each of the tryptophan, arginine, pyrimidine and glycerophospholipid metabolism pathways. The rosy mutation thus ramifies far more widely than previously detected.

Item type: Article
ID code: 9991
Keywords: Metabolomics, Fourier transform mass spectrometry, Drosophila, Therapeutics. Pharmacology, Biochemistry, Structural Biology, Cell Biology, Genetics, Molecular Biology, Biophysics
Subjects: Medicine > Therapeutics. Pharmacology
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Related URLs:
    Depositing user: Strathprints Administrator
    Date Deposited: 17 May 2010 16:42
    Last modified: 04 Sep 2014 21:25
    URI: http://strathprints.strath.ac.uk/id/eprint/9991

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