Graham, Duncan and Parkinson, John A. and Brown, Tom (1998) DNA duplexes stabilized by modified monomer residues: synthesis and stability. Journal of the Chemical Society, Perkin Transactions 1, 1998 (6). pp. 1131-1138. ISSN 1472-7781
Full text not available in this repository. (Request a copy from the Strathclyde author)Official URL: http://dx.doi.org/10.1039/a707031d
Abstract
The synthesis of a series of 2'-deoxyuridine analogues modified at the 5-position and a series of 2'-deoxypurines modified at the 8-position is described. Ultraviolet melting studies have been used to assess the stability of DNA duplexes 12- and 8-residues in length that contain these modifications. Of those modified residues which have been incorporated into oligonucleotides, 5-(prop-1-ynyl)-2'-deoxyuridine is found to impart the greatest increase in stability on the DNA duplexes studied.
| Item type: | Article |
|---|---|
| ID code: | 950 |
| Keywords: | substituted pyrimidine nucleosides, acid related-compounds, antiviral activity, oligonucleotides, oligodeoxynucleotides, 2'-deoxyuridine, derivatives, agents, cells, Chemistry |
| Subjects: | Science > Chemistry |
| Department: | Faculty of Science > Pure and Applied Chemistry |
| Related URLs: | |
| Depositing user: | Mr Derek Boyle |
| Date Deposited: | 04 May 2006 |
| Last modified: | 04 Oct 2012 15:17 |
| URI: | http://strathprints.strath.ac.uk/id/eprint/950 |
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