Mackellar, C. and Graham, D. and Will, D.W. and Burgess, S. and Brown, T. (1992) Synthesis and physical properties of anti-HIV antisense oligonucleotides bearing terminal lipophilic groups. Nucleic Acids Research, 20 (13). pp. 3411-3417. ISSN 0305-1048
Full text not available in this repository. (Request a copy from the Strathclyde author)Abstract
A number of phosphoramidite monomers have been prepared and used in the synthesis of antisense phosphorothioate oligonucleotides bearing 5'-polyalkyl and cholesterol moieties. Similar groups have also been attached to the 3'-end of oligonucleotides by means of functionalised CPG. Melting temperatures of duplexes formed between phosphorothioate oligonucleotides with lipophilic end-groups and complementary DNA strands were found to be identical to those formed by the equivalent unmodified phosphorothioates.
| Item type: | Article |
|---|---|
| ID code: | 947 |
| Keywords: | human immunodeficiency virus, phosphorothioate oligodeoxynucleotide, cells, derivatives, cholesterol, inhibitors, infection, invitro, Chemistry |
| Subjects: | Science > Chemistry |
| Department: | Faculty of Science > Pure and Applied Chemistry Faculty of Humanities And Social Sciences > History |
| Related URLs: | |
| Depositing user: | Mr Derek Boyle |
| Date Deposited: | 04 May 2006 |
| Last modified: | 12 Mar 2012 10:36 |
| URI: | http://strathprints.strath.ac.uk/id/eprint/947 |
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