Suckling, C.J. and Kununthur, S.R. and Gibson, C.L. and Wadsworth, R.M. (2005) Modulation of pulmonary vascular tone by novel analogues of tetrahydrobiopterin. Pteridines, 16 (112). ISSN 0933-4807
Full text not available in this repository. (Request a copy from the Strathclyde author)Abstract
Tetrahydrobiopterin (BH4), an essential cofactor for nitric oxide synthase (NOS), is a highly polar and unstable molecule, which is subject to autooxidation, which ultimately leads to superoxide production. Novel analogues of BH4, 6-hydroxymethylpterin (HMP) and 6-acetyl-7-dimethyldihydropterin (ADDP), which are radical intermediates having more stable oxidation states, were synthesized. To determine the potential use of the analogues as vasodilatory agents in reducing pulmonary hypertension, we studied their effects on normal pulmonary arteries as well as in pulmonary arteries depleted of endogenous reserves of BH4.
| Item type: | Article |
|---|---|
| ID code: | 932 |
| Keywords: | pulmonary vascular tone, novel analogues, tetrahydrobiopterin, Chemistry |
| Subjects: | Science > Chemistry |
| Department: | Faculty of Science > Pure and Applied Chemistry Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences |
| Related URLs: | |
| Depositing user: | Allison Crawford |
| Date Deposited: | 02 May 2006 |
| Last modified: | 12 Mar 2012 10:36 |
| URI: | http://strathprints.strath.ac.uk/id/eprint/932 |
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