Strathprints Home | Open Access | Browse | Search | User area | Copyright | Help | Library Home | SUPrimo

Modulation of pulmonary vascular tone by novel analogues of tetrahydrobiopterin

Suckling, C.J. and Kununthur, S.R. and Gibson, C.L. and Wadsworth, R.M. (2005) Modulation of pulmonary vascular tone by novel analogues of tetrahydrobiopterin. Pteridines, 16 (112). ISSN 0933-4807

Full text not available in this repository. (Request a copy from the Strathclyde author)

Abstract

Tetrahydrobiopterin (BH4), an essential cofactor for nitric oxide synthase (NOS), is a highly polar and unstable molecule, which is subject to autooxidation, which ultimately leads to superoxide production. Novel analogues of BH4, 6-hydroxymethylpterin (HMP) and 6-acetyl-7-dimethyldihydropterin (ADDP), which are radical intermediates having more stable oxidation states, were synthesized. To determine the potential use of the analogues as vasodilatory agents in reducing pulmonary hypertension, we studied their effects on normal pulmonary arteries as well as in pulmonary arteries depleted of endogenous reserves of BH4.

Item type: Article
ID code: 932
Keywords: pulmonary vascular tone, novel analogues, tetrahydrobiopterin, Chemistry, Biochemistry, Molecular Medicine, Clinical Biochemistry
Subjects: Science > Chemistry
Department: Faculty of Science > Pure and Applied Chemistry
Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Related URLs:
Depositing user: Allison Crawford
Date Deposited: 02 May 2006
Last modified: 04 Sep 2014 13:13
URI: http://strathprints.strath.ac.uk/id/eprint/932

Actions (login required)

View Item