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Design of a novel system for spectroscopy measurements of the aqueous humour

Miller, J. and Uttamchandani, D.G. (2001) Design of a novel system for spectroscopy measurements of the aqueous humour. Proceedings of SPIE: The International Society for Optical Engineering, 4253 (118). pp. 118-124.

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Abstract

The authors report on the design of a system which will enable real time measurements of (therapeutic) drug concentrations in the anterior chamber of the eye. Currently the concentration of therapeutic drugs in the anterior chamber is determined by analyzing samples which have been removed from the aqueous humor of laboratory animal eyes. This sampling via paracentesis can be painful and does not provide a continuous measurement. Our system will be far less invasive, removing the need for sampling via paracentesis, and also providing a continuous measurement, enabling a more complete understanding of the kinetics of ophthalmic drugs. A key component in our novel system is a specially constructed contact lens. We report on the design, optimization and manufacture of such a contact lens system capable of directing UV/VIS light in, across and out of the anterior chamber of the eye, thereby enabling absorption spectroscopy measurements of the aqueous humor to be undertaken. Design of the one piece contact lens/mirror system was achieved using the Zemax optical design software package and the lens was fabricated from synthetic fused silica. Results from modeling of the lens and experimental measurements on light propagation across the anterior chamber of animal eyes assisted by the lens will be reported.

Item type: Article
ID code: 8467
Keywords: drug concentrations, eye, paracentesis, ophthalmology, contact lens, drug detection, optoelectronic, ocular spectrometer, cornea, ocular drug detection, fluorescence spectroscopy, biomedical electronics, biomedical equipment, biomedical measurement, chemical sensors, optical fibres, optical sensors, optoelectronic devices, patient monitoring, patient treatment, spectrometers, Ophthalmology, Electrical engineering. Electronics Nuclear engineering, Condensed Matter Physics, Electronic, Optical and Magnetic Materials, Electrical and Electronic Engineering, Applied Mathematics, Computer Science Applications
Subjects: Medicine > Ophthalmology
Technology > Electrical engineering. Electronics Nuclear engineering
Department: Faculty of Engineering > Electronic and Electrical Engineering
Depositing user: Strathprints Administrator
Date Deposited: 03 Sep 2009 10:33
Last modified: 21 May 2015 10:11
URI: http://strathprints.strath.ac.uk/id/eprint/8467

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