Picture of virus under microscope

Research under the microscope...

The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs.

Strathprints serves world leading Open Access research by the University of Strathclyde, including research by the Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), where research centres such as the Industrial Biotechnology Innovation Centre (IBioIC), the Cancer Research UK Formulation Unit, SeaBioTech and the Centre for Biophotonics are based.

Explore SIPBS research

The influence of drug partition coefficient on follicular penetration: in vitro human skin studies

Frum, Y. and Bonner, M. and Eccleston, G.M. and Meidan, V.M. (2007) The influence of drug partition coefficient on follicular penetration: in vitro human skin studies. European Journal of Pharmaceutical Sciences, 30. pp. 280-287. ISSN 0928-0987

Full text not available in this repository. (Request a copy from the Strathclyde author)

Abstract

The aim of this study was to employ the novel skin sandwich system in order to quantify the influence of the octanol-water partition coefficient on follicular drug absorption in human skin. To this end, seven different drugs - estradiol, corticosterone, hydrocortisone, aldosterone, cimetidine, deoxyadenosine and adenosine - exhibiting a wide range of log octanol-water partition coefficients (logK0/w) but relatively similar molecular weights were selected as candidate solutes. Application of the skin sandwich technique yielded an interesting relationship between % follicular contribution and logKo/w The follicular contribution to total flux was small (4 and 2%) for the two most lipophilic drugs but varied between 34 and 60% for the remaining drugs of intermediate and low logKo/w values. Lipophilicity seems to be an important modulator of drug absorption into follicular orifices only above a critical logKo/w threshold. Below this critical logKo/w value, lipophilicity does not apparently influence the follicular contribution in an obvious way and the process is probably governed by other molecular properties. Identification of these other active properties would require performing this kind of a study on a much larger set of candidate drugs.