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The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs.

Strathprints serves world leading Open Access research by the University of Strathclyde, including research by the Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), where research centres such as the Industrial Biotechnology Innovation Centre (IBioIC), the Cancer Research UK Formulation Unit, SeaBioTech and the Centre for Biophotonics are based.

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Chronic toxicity of hexavalent chromium to U937 human monocyte cell line

Raghunathan, V.K. and Ellis, E.M. and Grant, M.H. (2006) Chronic toxicity of hexavalent chromium to U937 human monocyte cell line. In: BioScience 2006: Bioscience in the 21st Century, 2006-07-23 - 2006-07-27.

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Abstract

Cobalt chromium (CoCr) alloy and stainless steel are widely used in orthopaedic implants. Cr(VI) is known to be released when metals corrode in vivo (Milošev et al., 2005) and may be toxic to local cells like osteoblasts and macrophages. Ning and Grant, 2000 J. Ning and M.H. Grant, Toxicol. In Vitro 14 (2000), pp. 329-335. Article | PDF (185 K)(25)Ning and Grant (2000) have demonstrated the acute toxicity of Cr(VI) to immortalised rat osteoblasts and shown the involvement of reduced glutathione (GSH) and glutathione reductase (GRd) in the interaction. This paper details the chronic toxicity of hexavalent chromium to U937 human monocyte cell lines.