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Chronic toxicity of hexavalent chromium to U937 human monocyte cell line

Raghunathan, V.K. and Ellis, E.M. and Grant, M.H. (2006) Chronic toxicity of hexavalent chromium to U937 human monocyte cell line. In: BioScience 2006: Bioscience in the 21st Century, 2006-07-23 - 2006-07-27, Glasgow, Scotland.

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Abstract

Cobalt chromium (CoCr) alloy and stainless steel are widely used in orthopaedic implants. Cr(VI) is known to be released when metals corrode in vivo (Milošev et al., 2005) and may be toxic to local cells like osteoblasts and macrophages. Ning and Grant, 2000 J. Ning and M.H. Grant, Toxicol. In Vitro 14 (2000), pp. 329-335. Article | PDF (185 K)(25)Ning and Grant (2000) have demonstrated the acute toxicity of Cr(VI) to immortalised rat osteoblasts and shown the involvement of reduced glutathione (GSH) and glutathione reductase (GRd) in the interaction. This paper details the chronic toxicity of hexavalent chromium to U937 human monocyte cell lines.

Item type: Conference or Workshop Item (Paper)
ID code: 8441
Keywords: Bioengineering
Subjects: Technology > Engineering (General). Civil engineering (General) > Bioengineering
Department: Faculty of Engineering > Bioengineering
Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Related URLs:
Depositing user: Strathprints Administrator
Date Deposited: 30 Jul 2009 16:22
Last modified: 04 Oct 2012 17:19
URI: http://strathprints.strath.ac.uk/id/eprint/8441

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