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Modification of plasticised poly (vinyl chloride)

Zhao, X.B. and Courtney, J.M. (2006) Modification of plasticised poly (vinyl chloride). In: Focus on Polymeric Materials Research. Nova Science, pp. 1-27. ISBN 1-59454-843-9

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Abstract

Surface modification of plasticised poly (vinyl chloride) (PVC), with di-(2-ethylhexyl) phthalate (DEHP) as plasticiser, for the improvement of blood compatibility in potential clinical use such as cardiopulmonary bypass was achieved by heparinisation. The influence of surface modification on blood compatibility was assessed in terms of the influence on fibrinogen and factor XII adsorption in vitro, and the generation of thrombin-antithrombin III complex (TAT) and the complement component C3a, in vitro and ex vivo. Electron spectroscopy for chemical analysis (ESCA) was used to characterise the heparinised surface in order to correlate the surface properties with the blood response. Results indicate that at the plasticised PVC surface there is a higher content of heparin than that of the PVC and the DEHP content is lower than that present at the surface of standard plasticised PVC. The blood compatibility assessment confirms the importance of surface modification for the improvement of blood compatibility.

Item type: Book Section
ID code: 8405
Keywords: plasticised poly (vinyl chloride), polymers, ceramics, bioengineering, Bioengineering, Chemistry
Subjects: Technology > Engineering (General). Civil engineering (General) > Bioengineering
Science > Chemistry
Department: Faculty of Engineering > Bioengineering
Related URLs:
Depositing user: Strathprints Administrator
Date Deposited: 07 Aug 2009 12:23
Last modified: 12 Mar 2012 10:49
URI: http://strathprints.strath.ac.uk/id/eprint/8405

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