Zhao, Xiaobin and Courtney, James M. (2006) Surface modification of polymeric biomaterials: utilization of cyclodextrins for blood compatibility improvement. Journal of Biomedical Materials Research Part A, 80A (3). pp. 539-553. ISSN 1549-3296Full text not available in this repository. (Request a copy from the Strathclyde author)
A novel modified polymeric biomaterial surface using cyclodextrins (CDs) for improved blood compatibility was studied. Plasticized poly(vinyl chloride) (PVC-P) was selected for modification and polyethylene was used as a reference material. The modification was achieved by polymer blending. Fibrinogen and albumin adsorption were utilized as indices for the assessment of the blood compatibility. Surface characterization confirmed that CDs were able to accumulate at the PVC surface and alter the surface properties. The combination of other hydrophilic polymers such as poly(ethylene oxide) (PEO) and PEO/poly(propylene oxide) (PPO) copolymers, such as Pluronic F68 (F68), with CDs were also investigated. These modified materials have a remarkable protein-resistant surface. The combination of B-cyclodextrin (B-CD)/PEO and B-CD/F68 in certain feeding ratio are synergistic in producing enhanced blood compatibility.
|Keywords:||plasticized poly(vinyl chloride), cyclodextrins, blood compatibility, protein adsorption, surface modification, polymer blending, bioengineering, Bioengineering, Medicine(all)|
|Subjects:||Technology > Engineering (General). Civil engineering (General) > Bioengineering|
|Department:||Faculty of Engineering > Bioengineering|
|Depositing user:||Strathprints Administrator|
|Date Deposited:||04 Aug 2009 10:17|
|Last modified:||29 Apr 2016 09:51|