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Surface modification of polymeric biomaterials: utilization of cyclodextrins for blood compatibility improvement

Zhao, Xiaobin and Courtney, James M. (2006) Surface modification of polymeric biomaterials: utilization of cyclodextrins for blood compatibility improvement. Journal of Biomedical Materials Research Part A, 80A (3). pp. 539-553. ISSN 1549-3296

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Abstract

A novel modified polymeric biomaterial surface using cyclodextrins (CDs) for improved blood compatibility was studied. Plasticized poly(vinyl chloride) (PVC-P) was selected for modification and polyethylene was used as a reference material. The modification was achieved by polymer blending. Fibrinogen and albumin adsorption were utilized as indices for the assessment of the blood compatibility. Surface characterization confirmed that CDs were able to accumulate at the PVC surface and alter the surface properties. The combination of other hydrophilic polymers such as poly(ethylene oxide) (PEO) and PEO/poly(propylene oxide) (PPO) copolymers, such as Pluronic F68 (F68), with CDs were also investigated. These modified materials have a remarkable protein-resistant surface. The combination of B-cyclodextrin (B-CD)/PEO and B-CD/F68 in certain feeding ratio are synergistic in producing enhanced blood compatibility.