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Assessment of drug permeability distributions in two different model skins

Khan, G.M. and Frum, Y. and Sarheed, O.A. and Eccleston, G.M. and Meidan, V.M. (2005) Assessment of drug permeability distributions in two different model skins. International Journal of Pharmaceutics, 303 (1-2). pp. 81-87. ISSN 0378-5173

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Abstract

Past in vitro studies with human skin have indicated that drug permeability coefficient (Kp) distributions do not always follow a Gaussian-normal pattern. This has major statistical implications, exemplified by the fact that use of t-tests to evaluate significance is limited to normally distributed populations. Percutaneous absorption research often involves using animal or synthetic skins to simulate less readily available human skin. However, negligible work has been performed on assessing the permeability variabilities of these model membranes. This paper aims to fill this gap. To this end, four studies were undertaken representing two different drugs (caffeine and testosterone) with each drug penetrating through two different model skins (silicone membrane and pig skin). It was determined that in the silicone membrane studies, both compounds' Kp distributions could be fitted to a normal pattern. In contrast, in the pig skin studies, there were notable differences between each drug. While the testosterone Kp values could be fitted to a normal distribution, this was not possible with the caffeine Kp data, which could be fitted to a log-normal distribution. There is some evidence from the literature as well as physicochemical considerations that these outcomes may reflect general trends that are dependent upon both membrane and penetrant properties.

Item type: Article
ID code: 8381
Keywords: testosterone, caffeine, skin, permeability coefficient, variability, Gaussian distribution, Bioengineering, Therapeutics. Pharmacology, Pharmaceutical Science
Subjects: Technology > Engineering (General). Civil engineering (General) > Bioengineering
Medicine > Therapeutics. Pharmacology
Department: Faculty of Engineering > Bioengineering
Unknown Department
Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Related URLs:
    Depositing user: Strathprints Administrator
    Date Deposited: 04 Aug 2009 12:19
    Last modified: 04 Sep 2014 19:47
    URI: http://strathprints.strath.ac.uk/id/eprint/8381

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