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Reverse iontophoresis: a non-invasive technique for measuring blood lactate level

Ching, C.T.S. and Connolly, P. (2008) Reverse iontophoresis: a non-invasive technique for measuring blood lactate level. Sensors and Actuators B: Chemical, 129 (1). pp. 352-358. ISSN 0925-4005

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Abstract

Blood lactate monitoring is beneficial to many patients, e.g. critical care patients. However, there are very few non-invasive or continuous monitoring systems for this parameter and significant clinical benefit could be achieved if such systems were readily available. Therefore, the aim of the current study was to investigate the possibility of non-invasively extracting lactate from blood through skin using reverse iontophoresis to monitor blood lactate levels in humans. In vitro reverse iontophoresis studies have indicated that the optimum switching mode for reverse iontophoresis of lactate is continuous direct current but application of current combined with electrode polarity reversal every 15 min was suggested to be used in humans. The reverse iontophoresis technique was applied to 10 healthy volunteers and lactate was successfully extracted through their skin into the methylcellulose gel of the electrodes. A moderate correlation (r2 = 0.6) between lactate concentrations in collection gels and lactate levels in the blood was observed after an outlier was removed from the regression equation. The result suggests that it may be possible to non-invasively monitor the blood lactate levels using reverse iontophoresis technique.

Item type: Article
ID code: 8337
Keywords: reverse iontophoresis, iontophoresis, lactate, monitoring, non-invasive, bioengineering, Bioengineering, Physiology, Materials Chemistry, Instrumentation, Surfaces, Coatings and Films, Metals and Alloys, Electronic, Optical and Magnetic Materials, Electrical and Electronic Engineering, Condensed Matter Physics
Subjects: Technology > Engineering (General). Civil engineering (General) > Bioengineering
Science > Physiology
Department: Faculty of Engineering > Bioengineering
Related URLs:
    Depositing user: Strathprints Administrator
    Date Deposited: 04 Aug 2009 14:36
    Last modified: 04 Sep 2014 21:22
    URI: http://strathprints.strath.ac.uk/id/eprint/8337

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