Picture of athlete cycling

Open Access research with a real impact on health...

The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by Strathclyde researchers, including by researchers from the Physical Activity for Health Group based within the School of Psychological Sciences & Health. Research here seeks to better understand how and why physical activity improves health, gain a better understanding of the amount, intensity, and type of physical activity needed for health benefits, and evaluate the effect of interventions to promote physical activity.

Explore open research content by Physical Activity for Health...

Reverse iontophoresis: a non-invasive technique for measuring blood lactate level

Ching, C.T.S. and Connolly, P. (2008) Reverse iontophoresis: a non-invasive technique for measuring blood lactate level. Sensors and Actuators B: Chemical, 129 (1). pp. 352-358. ISSN 0925-4005

Full text not available in this repository. Request a copy from the Strathclyde author

Abstract

Blood lactate monitoring is beneficial to many patients, e.g. critical care patients. However, there are very few non-invasive or continuous monitoring systems for this parameter and significant clinical benefit could be achieved if such systems were readily available. Therefore, the aim of the current study was to investigate the possibility of non-invasively extracting lactate from blood through skin using reverse iontophoresis to monitor blood lactate levels in humans. In vitro reverse iontophoresis studies have indicated that the optimum switching mode for reverse iontophoresis of lactate is continuous direct current but application of current combined with electrode polarity reversal every 15 min was suggested to be used in humans. The reverse iontophoresis technique was applied to 10 healthy volunteers and lactate was successfully extracted through their skin into the methylcellulose gel of the electrodes. A moderate correlation (r2 = 0.6) between lactate concentrations in collection gels and lactate levels in the blood was observed after an outlier was removed from the regression equation. The result suggests that it may be possible to non-invasively monitor the blood lactate levels using reverse iontophoresis technique.