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The cellular response to a polyurethane surface modified with vascular extracellular matrix proteins - towards the development of a cell-seeded small-diameter vascular graft

Smith, K.H. and Jozwiak, A.B. and Bax, D.V. and Kielty, C.M. and Black, R.A. (2007) The cellular response to a polyurethane surface modified with vascular extracellular matrix proteins - towards the development of a cell-seeded small-diameter vascular graft. Tissue Engineering, 13 (7). p. 1762. ISSN 1076-3279

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Abstract

The aim of this work is to develop an artificial artery for use in bypass surgery. The hybrid artery consists of a porous tubular scaffold made from a polyurethane elastomer. The surface of the polymer is then modified with recombinant proteins in order to encourage the growth of organised layers of vascular cells.