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Flying spot en face OCT for monitoring cell distribution in collagen-based constructs

Kosmidis, K. and Russell, Christopher D. and Dobre, George and Podoleanu, Adrian Gh. and Black, R.A. (2007) Flying spot en face OCT for monitoring cell distribution in collagen-based constructs. Multiphoton Microscopy in the Biomedical Sciences IV (Proceedings of SPIE), 6079. 60790Q-1. ISSN 1605-7422

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Abstract

The use of optical coherence tomography (OCT) as a monitoring tool in the growth of human fibroblasts cells in collagen-based constructs is investigated. Rat-tail tendon type-1 collagen based gels mixed with human fibroblasts were prepared and incubated. Fixed samples were then imaged using OCT, and subsequently cross-sectioned and analysed microscopically. The concentration of cells in samples under different contraction dynamics was investigated using analysis of the OCT images. Results show clear differences in scattering intensity as a consequence of cell concentration in both OCT images and micrographs.

Item type: Article
ID code: 8331
Notes: Biomedical Optics Conference, San Jose, 21-26 Jan. 2006 Progress in Biomedical Optics and Imaging, Vol. 7, No. 2, 2006
Keywords: optical coherence tomography, collagen gels, cell distribution, tissue engineering, Bioengineering, Physiology, Condensed Matter Physics, Electronic, Optical and Magnetic Materials, Electrical and Electronic Engineering, Applied Mathematics, Computer Science Applications
Subjects: Technology > Engineering (General). Civil engineering (General) > Bioengineering
Science > Physiology
Department: Faculty of Engineering > Bioengineering
Related URLs:
    Depositing user: Strathprints Administrator
    Date Deposited: 04 Aug 2009 15:33
    Last modified: 23 Jul 2014 05:02
    URI: http://strathprints.strath.ac.uk/id/eprint/8331

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