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Open Access research that challenges the mind...

The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs. Strathprints provides access to thousands of Open Access research papers by University of Strathclyde researchers, including those from the School of Psychological Sciences & Health - but also papers by researchers based within the Faculties of Science, Engineering, Humanities & Social Sciences, and from the Strathclyde Business School.

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Improvements in alzheimer's disease diagnosis using principle components analysis (PCA) in combination with raman spectroscopy

Archer, J.K.J. and Sudworth, C.D. and Black, R.A. and Williams, Rachel and How, Thien and Stone, Nicholas and Mann, David (2007) Improvements in alzheimer's disease diagnosis using principle components analysis (PCA) in combination with raman spectroscopy. Proceedings of SPIE the International Society for Optical Engineering, 6628. p. 662810. ISSN 0277-786X

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Abstract

The use of optical coherence tomography (OCT) as a monitoring tool in the growth of human fibroblasts cells in collagen-based constructs is investigated. Rat-tail tendon type-1 collagen based gels mixed with human fibroblasts were prepared and incubated. Fixed samples were then imaged using OCT, and subsequently cross-sectioned and analysed microscopically. The concentration of cells in samples under different contraction dynamics was investigated using analysis of the OCT images. Results show clear differences in scattering intensity as a consequence of cell concentration in both OCT images and micrographs.