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Changes in cerebal vascular reactivity occur early during cardiopulmonary bypass in the rat

Modine, T. and Azzaoui, R. and Ouk, T. and Fayad, G. and Lacroix, D. and Warembourg, H. and Bordet, R. and Gourlay, T. (2006) Changes in cerebal vascular reactivity occur early during cardiopulmonary bypass in the rat. Annals of Thoracic Surgery, 82. pp. 672-678. ISSN 0003-4975

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Abstract

Cardiopulmonary bypass (CPB) is known to cause cerebrovascular dysfunction. The etiology of these complications is complex, but disruption of normal cerebral endothelial function as a consequence of inflammatory or hypoperfusion phenomena have been implicated. The aim of this study was to investigate the effect of CPB time on cerebrovascular reactivity and to investigate the correlation of these findings with measured inflammatory markers. Cerebrovascular impairment appears early after the onset of CPB. The specific loss of acetylcholine-induced vasodilation suggests endothelial cell dysfunction rather than impaired vascular smooth muscle response to nitric oxide. This loss of endothelium-dependent regulatory factors after CPB may enhance vasoconstriction, impair cerebrovascular function, and contribute to neurologic injury after CPB.