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Open Access research that challenges the mind...

The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs. Strathprints provides access to thousands of Open Access research papers by University of Strathclyde researchers, including those from the School of Psychological Sciences & Health - but also papers by researchers based within the Faculties of Science, Engineering, Humanities & Social Sciences, and from the Strathclyde Business School.

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Micro-LED arrays: a tool for two-dimensional neuron stimulation

Poher, V. and Grossman, N. and Kennedy, G.T. and Nikolic, K. and Zhang, H.X. and Gong, Z. and Drakakis, E.M. and Gu, E. and Dawson, M.D. and French, P.M.W. and Degenaar, P. and Neil, M.A.A. (2008) Micro-LED arrays: a tool for two-dimensional neuron stimulation. Journal of Physics D: Applied Physics, 41 (9). 094014. ISSN 0022-3727

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Stimulating neuron cells with light is an exciting new technology that is revolutionizing the neurosciences. To date, due to the optical complexity that is involved, photostimulation has only been achieved at a single site using high power light sources. Here we present a GaN based micro-light emitting diode (LED) array that can open the way to multi-site photostimulation of neuron cells. The device is a two-dimensional array of micrometre size LED emitters. Each emitter has the required wavelength, optical power and modulation bandwidth to trigger almost any photosensitizer and is individually addressable. We demonstrate micrometre resolution photoactivation of a caged fluorophore and photostimulation of sensitized living neuron cells. In addition, a complete system that combines the micro-LED array with multi-site electrophysiological recording based on microelectrode array technology and/or fluorescence imaging is presented.