Hoskisson, P. and Sharples, G.P. and Hobbs, G. (2005) Differentiation and protease production in Micromonospora echinospora (ATCC 15837). Antonie van Leeuwenhoek, 89 (1). pp. 191-195. ISSN 0003-6072Full text not available in this repository. (Request a copy from the Strathclyde author)
Micromonospora echinospora differentiates in both submerged and surface cultures producing abundant dark spores after a period of vegetative mycelial growth. In submerged batch cultures, under either carbon or nitrogen limiting conditions, protease activity was found to coincide with sporulation indicating a relationship between proteolytic activity and differentiation in this organism. Further evidence for this link was provided from surface grown cultures wherein sporulation was inhibited by the serine protease inhibitors TLCK and TPCK. The association between proteolysis and differentiation apparent in this organism correlates with evidence of a similar phenomenon observed in the streptomycetes, suggesting that this may be a common response associated with differentiation in filamentous actinomycetes.
|Keywords:||protease production, micromonospora echinospora, sporulation, differentiation, Pharmacy and materia medica, Molecular Biology, Microbiology|
|Subjects:||Medicine > Pharmacy and materia medica|
|Department:||Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences|
|Depositing user:||Strathprints Administrator|
|Date Deposited:||28 Feb 2009 15:15|
|Last modified:||06 Jan 2017 05:55|