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(How) do aluminium adjuvants work?

Brewer, J.M. (2006) (How) do aluminium adjuvants work? Immunology Letters, 102 (1). pp. 10-15. ISSN 0165-2478

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Abstract

The aluminium compounds, originally identified as adjuvants over 70 years ago, remain unique in their widespread application to human vaccines. Given this history, it is surprising that the physicochemical interactions between aluminium compounds and antigens are relatively poorly understood. This has clearly been a contributing factor to vaccine failures, for example, through inappropriate selection of aluminium species or buffers. Similarly, the mechanism(s) of action of aluminium adjuvants are relatively unstudied, although it appears that these agents fail to fit within the current principles underlying activation of the immune response. This review aims to examine recent developments in our understanding of the physicochemical and biological aspects of research into aluminium adjuvants.

Item type: Article
ID code: 7619
Keywords: aluminium adjuvant, vaccine, dendritic cells, Pharmacy and materia medica, Immunology, Immunology and Allergy
Subjects: Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Related URLs:
    Depositing user: Strathprints Administrator
    Date Deposited: 10 Mar 2009 15:58
    Last modified: 04 Sep 2014 16:56
    URI: http://strathprints.strath.ac.uk/id/eprint/7619

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