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Insulin-like growth factor-binding protein-5 (IGFBP-5): a critical member of the IGF axis

Beattie, James and Allan, Gordon J. and Lochrie, Jennifer D. and Flint, David J. (2006) Insulin-like growth factor-binding protein-5 (IGFBP-5): a critical member of the IGF axis. Biochemical Journal, 395. pp. 1-19. ISSN 0264-6021

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Abstract

The six members of the insulin-like growth factor-binding protein family (IGFBP-1-6) are important components of the IGF (insulin-like growth factor) axis. In this capacity, they serve to regulate the activity of both IGF-I and -II polypeptide growth factors. The IGFBPs are able to enhance or inhibit the activity of IGFs in a cell- and tissue-specific manner. One of these proteins, IGFBP-5, also has an important role in controlling cell survival, differentiation and apoptosis. In this review, we report on the structural and functional features of the protein which are important for these effects. We also examine the regulation of IGFBP-5 expression and comment on its potential role in tumour biology, with special reference to work with breast cancer cells.

Item type: Article
ID code: 7614
Keywords: extracellular matrix (ECM), glycosaminoglycan, insulin-like growth factor-I (IGF-I), insulin-like growth, factor-binding protein 5, mammary gland, proteolysis, review, Pharmacy and materia medica
Subjects: Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Related URLs:
    Depositing user: Strathprints Administrator
    Date Deposited: 10 Mar 2009 14:58
    Last modified: 16 Jul 2013 20:33
    URI: http://strathprints.strath.ac.uk/id/eprint/7614

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