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Transdermal and buccal delivery of methylxanthines through human tissue in vitro

Thakur, R.A. and Michniak, B.B. and Meidan, V.M. (2007) Transdermal and buccal delivery of methylxanthines through human tissue in vitro. Drug Development and Industrial Pharmacy, 33 (5). pp. 513-521. ISSN 0363-9045

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Abstract

We examined the in vitro permeation of central nervous stimulants-caffeine, theophylline, and theobromine across human skin with the aid of six chemical enhancers. It was found that oleic acid was the most potent enhancer for all three methylxanthines. Further optimization studies with different solvents showed that caffeine transport could be enhanced to give flux values up to 585 μg/cm2.hr-1. Theobromine and theophylline delivery rates proved insufficient. An additional study involving a buccal tissue equivalent showed that this membrane was more permeable than skin for all model actives tested and would offer an alternate way of delivery.

Item type: Article
ID code: 7588
Keywords: transdermal, buccal, oleic acid, terpenes, caffeine, theobromine, theophylline, Pharmacy and materia medica, Organic Chemistry, Drug Discovery, Pharmacology
Subjects: Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
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Depositing user: Strathprints Administrator
Date Deposited: 10 Mar 2009 16:40
Last modified: 04 Sep 2014 17:55
URI: http://strathprints.strath.ac.uk/id/eprint/7588

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