Thakur, R.A. and Michniak, B.B. and Meidan, V.M. (2007) Transdermal and buccal delivery of methylxanthines through human tissue in vitro. Drug Development and Industrial Pharmacy, 33 (5). pp. 513-521. ISSN 0363-9045
Full text not available in this repository. (Request a copy from the Strathclyde author)Abstract
We examined the in vitro permeation of central nervous stimulants-caffeine, theophylline, and theobromine across human skin with the aid of six chemical enhancers. It was found that oleic acid was the most potent enhancer for all three methylxanthines. Further optimization studies with different solvents showed that caffeine transport could be enhanced to give flux values up to 585 μg/cm2.hr-1. Theobromine and theophylline delivery rates proved insufficient. An additional study involving a buccal tissue equivalent showed that this membrane was more permeable than skin for all model actives tested and would offer an alternate way of delivery.
| Item type: | Article |
|---|---|
| ID code: | 7588 |
| Keywords: | transdermal, buccal, oleic acid, terpenes, caffeine, theobromine, theophylline, Pharmacy and materia medica |
| Subjects: | Medicine > Pharmacy and materia medica |
| Department: | Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences |
| Related URLs: | |
| Depositing user: | Strathprints Administrator |
| Date Deposited: | 10 Mar 2009 16:40 |
| Last modified: | 04 Oct 2012 12:21 |
| URI: | http://strathprints.strath.ac.uk/id/eprint/7588 |
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