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The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs.

Strathprints serves world leading Open Access research by the University of Strathclyde, including research by the Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), where research centres such as the Industrial Biotechnology Innovation Centre (IBioIC), the Cancer Research UK Formulation Unit, SeaBioTech and the Centre for Biophotonics are based.

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Transdermal and buccal delivery of methylxanthines through human tissue in vitro

Thakur, R.A. and Michniak, B.B. and Meidan, V.M. (2007) Transdermal and buccal delivery of methylxanthines through human tissue in vitro. Drug Development and Industrial Pharmacy, 33 (5). pp. 513-521. ISSN 0363-9045

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Abstract

We examined the in vitro permeation of central nervous stimulants-caffeine, theophylline, and theobromine across human skin with the aid of six chemical enhancers. It was found that oleic acid was the most potent enhancer for all three methylxanthines. Further optimization studies with different solvents showed that caffeine transport could be enhanced to give flux values up to 585 μg/cm2.hr-1. Theobromine and theophylline delivery rates proved insufficient. An additional study involving a buccal tissue equivalent showed that this membrane was more permeable than skin for all model actives tested and would offer an alternate way of delivery.