Picture of wind turbine against blue sky

Open Access research with a real impact...

The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs.

The Energy Systems Research Unit (ESRU) within Strathclyde's Department of Mechanical and Aerospace Engineering is producing Open Access research that can help society deploy and optimise renewable energy systems, such as wind turbine technology.

Explore wind turbine research in Strathprints

Explore all of Strathclyde's Open Access research content

Interleukin-18 enhances a Th2 biased response and susceptibility to leishmania mexicana in BALB/c mice

Alexander, J. and Bryson, K.J. and Wei, X. (2008) Interleukin-18 enhances a Th2 biased response and susceptibility to leishmania mexicana in BALB/c mice. Microbes and Infection, 10 (7). pp. 834-839. ISSN 1286-4579

Full text not available in this repository. (Request a copy from the Strathclyde author)

Abstract

Interleukin-18 deficient mice on a BALB/c background display increased resistance to cutaneous infection with Leishmania mexicana, with reduced lesion progression and reduced parasite burdens compared with wild-type mice. Infected IL-18−/− mice had lower antigen specific IgG1 levels and total IgE levels and conversely higher antigen specific IgG2a levels than similarly infected wild-type mice. Splenocytes isolated from infected IL-18−/− mice produced significantly lower levels of antigen induced IL-4 and higher levels of IFN-γ than wild-type animals. Consequently IL-18 during L. mexicana infection of BALB/c mice promotes a Th2 biased response and thereby has a disease exacerbating role.