Picture of athlete cycling

Open Access research with a real impact on health...

The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by Strathclyde researchers, including by researchers from the Physical Activity for Health Group based within the School of Psychological Sciences & Health. Research here seeks to better understand how and why physical activity improves health, gain a better understanding of the amount, intensity, and type of physical activity needed for health benefits, and evaluate the effect of interventions to promote physical activity.

Explore open research content by Physical Activity for Health...

New probes and optical spectroscopies for immune parasitological applications

Alexander, J. and Graham, D. (2006) New probes and optical spectroscopies for immune parasitological applications. Parasite Immunology, 28 (6). pp. 236-237. ISSN 0141-9838

Full text not available in this repository. Request a copy from the Strathclyde author

Abstract

The advent of monoclonal antibody technology in the 1970s heralded a massive expansion in immunological research and provided the tools linked to optical spectroscopies to rapidly and accurately diagnose disease, localize targets, phenotype cells, deplete cell populations, purify cell populations, and quantify physiological and immunological mediators. However, there is always a demand for the development of new ultra sensitive, ultra specific, and more flexible high throughput technologies. This requires either utilizing more refined and powerful probes than monoclonal antibodies to bind to targets, or using new more sensitive optical spectroscopies to localize and quantify readouts from the signals generated following binding, or a combination of both of these factors. Aptamers (= to fit), first described in 1990 (1,2) as a substitute for antibodies, may be the ideal tools to fulfil the first requirement. However, their use in immunoparasitological systems remains limited and awaits further exploitation.