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Particle separation in microfluidic devices - SPLITT fractionation and microfluidics

Zhang, Yonghao and Barber, Robert W. and Emerson, David (2005) Particle separation in microfluidic devices - SPLITT fractionation and microfluidics. Current Analytical Chemistry, 1 (3). pp. 345-354. ISSN 1573-4110

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In recent years, microfluidic devices have been increasingly used to separate particles such as colloids, macromolecules, cells, beads and droplets. Miniaturisation often introduces new functionalities and paradigms that are not possible at conventional macroscopic scales. In this paper, split-flow-thin fractionation techniques for particle separation are reviewed and the underlying physics of particle migration is discussed. The potential of these particle separation techniques in the design of integrated microfluidic systems is described. We then illustrate how numerical simulation can provide an increased understanding of the fluid-particle motion. The advantages of numerical simulation for rational design and operation of microfluidic devices are highlighted through two practical examples involving an ultrasonic cell washing system and a quadrupole magnetic flow sorter.

Item type: Article
ID code: 6972
Keywords: splitt fractionation, microfluidics, particle separation, Mechanical engineering and machinery, Chemistry, Analytical Chemistry
Subjects: Technology > Mechanical engineering and machinery
Science > Chemistry
Department: Faculty of Engineering > Mechanical and Aerospace Engineering
Depositing user: Strathprints Administrator
Date Deposited: 18 Sep 2008
Last modified: 21 Oct 2015 20:49

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