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The in vitro adsorption of cytokines by polymer-pyrolysed carbon

Howell, C.A. and Sandeman, S.R. and Phillips, G.J. and Lloyd, A.W. and Davies, J.A. and Mikhalovsky, S.V. and Tennison, S.R. and Rawlinson, A.P. and Kozynchenko, O.P. and Owen, H.L.H. and Gaylor, J.D.S. and Rouse, J.J. and Courtney, J.M. (2006) The in vitro adsorption of cytokines by polymer-pyrolysed carbon. Biomaterials, 27 (30). pp. 5286-5291. ISSN 0142-9612

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Abstract

This study investigated a range of phenolformaldehydeaniline based pyrolysed carbon matrices and their component materials, for their ability to adsorb a range of inflammatory cytokines crucial to the progression of sepsis. The efficiency of adsorption of the target molecules from human plasma was assessed and compared to that of Adsorba® 300C, a commercially available cellulose-coated activated charcoal. Results indicate that a number of the primary carbon/resin materials demonstrate efficient adsorption of the cytokines studied here (TNF, IL-6 and IL-8), comparable to other adsorbents under clinical investigation. Our findings also illustrate that these adsorbent capabilities are retained when the primary particles are combined to form a pyrolysed carbon matrix. This capability will enable the engineering of the carbon matrix porosity allowing a blend of carbonised particle combinations to be tailored for maximum adsorption of inflammatory cytokines. The present findings support further investigation of this carbon material as a combined carbon-based filtration/adsorbent device for direct blood purification.

Item type: Article
ID code: 6798
Keywords: adsorption, carbon, cytokine, extracorporeal circulation, sepsis, bioengineering, Bioengineering, Medicine (General), Human anatomy, Biomaterials, Bioengineering, Mechanics of Materials, Ceramics and Composites, Biophysics
Subjects: Technology > Engineering (General). Civil engineering (General) > Bioengineering
Medicine > Medicine (General)
Science > Human anatomy
Department: Faculty of Engineering > Bioengineering
Faculty of Law, Arts and Social Sciences > Geography and Sociology
Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Related URLs:
    Depositing user: Strathprints Administrator
    Date Deposited: 01 Sep 2008
    Last modified: 04 Sep 2014 17:04
    URI: http://strathprints.strath.ac.uk/id/eprint/6798

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