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The effects of inducing agents on the metabolism of pentamidine by isolated rat hepatocytes

Atsriku, C. and Grant, M.H. and Skellern, G.G. and Watson, D.G. (2004) The effects of inducing agents on the metabolism of pentamidine by isolated rat hepatocytes. Toxicology, 194 (3). pp. 234-235. ISSN 0300-483X

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Abstract

Abstract of toxicology paper. The aromatic diamidine, pentamidine isethionate, has been used for over four decades for the chemotherapy of African human trypanosomiasis (sleeping sickness) in affected areas world-wide (Goa and Campoli-Richards, 1987). Pentamidine (P) is also used for the treatment of Pneumocyctis carinii pneumonia commonly associated with AIDS victims and over 45% of patients who receive the drug are known to suffer severe adverse reactions (Sands et al., 1985). However, emergence of drug resistant strains of trypanosomes has become a major barrier to the efficacy of trypanocidal diamidines (Peregrine, 1994). In view of poor prospects for new drug development, attempts to sustain efficacy of the drug have focussed on research into the causes of parasite drug resistance as well as drug toxicity. The inhibition or induction of hepatic drug metabolising enzymes following multiple drug therapy or exposure to environmental chemicals can alter the metabolism profile and pharmacokinetics of a given drug, leading to either a toxicological response or therapeutic failure. The aim of this study was to investigate the effects of two classical cytochrome P450 inducers, phenobarbitone (PB) and 3-methylcholanthrene (3MC), as well as a pyrethroid insecticide, deltamethrin (DM), on the metabolism of P by isolated rat hepatocytes.

Item type: Article
ID code: 6783
Keywords: pentamidine, diminazene, inducing agents, hepatocytes, liquid chromatography-electrospray, ionisation, mass spectrometry, Bioengineering, Medicine (General), Human anatomy, Toxicology
Subjects: Technology > Engineering (General). Civil engineering (General) > Bioengineering
Medicine > Medicine (General)
Science > Human anatomy
Department: Faculty of Engineering > Bioengineering
Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Related URLs:
Depositing user: Strathprints Administrator
Date Deposited: 29 Aug 2008
Last modified: 04 Sep 2014 15:47
URI: http://strathprints.strath.ac.uk/id/eprint/6783

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