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Dementia on a chip : monitoring synaptic dysfunction of patient derived human neurons

Robertson, G. and Sposito, T. and Wray, S. and Hardy, J. and Bushell, T.J. and Zagnoni, M. (2016) Dementia on a chip : monitoring synaptic dysfunction of patient derived human neurons. In: 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016). Chemical and Biological Microsystems Society, San Diego, California, pp. 379-380. ISBN 9781510834163

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Abstract

Using patient derived induced pluripotent stem cells (iPSCs) with a genetic mutation in the tau gene (MAPT) we can model specific aspects of dementia in an on-chip platform. We have developed a microfluidic system to characterise synaptic communication between healthy and mutation-carrying networked neurons where synaptic maturity has been accelerated using human astrocyte co-cultures.