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The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by Strathclyde researchers, including by researchers from the Physical Activity for Health Group based within the School of Psychological Sciences & Health. Research here seeks to better understand how and why physical activity improves health, gain a better understanding of the amount, intensity, and type of physical activity needed for health benefits, and evaluate the effect of interventions to promote physical activity.

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Dementia on a chip : monitoring synaptic dysfunction of patient derived human neurons

Robertson, G. and Sposito, T. and Wray, S. and Hardy, J. and Bushell, T.J. and Zagnoni, M. (2016) Dementia on a chip : monitoring synaptic dysfunction of patient derived human neurons. In: 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016). Chemical and Biological Microsystems Society, San Diego, California, pp. 379-380. ISBN 9781510834163

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Abstract

Using patient derived induced pluripotent stem cells (iPSCs) with a genetic mutation in the tau gene (MAPT) we can model specific aspects of dementia in an on-chip platform. We have developed a microfluidic system to characterise synaptic communication between healthy and mutation-carrying networked neurons where synaptic maturity has been accelerated using human astrocyte co-cultures.