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From emulsion to single-phase microfluidics : an integrated approach to culture and perfusion of multicellular spheroids

McMillan, Kay S and Boyd, Marie and Zagnoni, Michele (2016) From emulsion to single-phase microfluidics : an integrated approach to culture and perfusion of multicellular spheroids. In: 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016). Chemical and Biological Microsystems Society, San Diego, CA, pp. 399-400. ISBN 9781510834163

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Abstract

This study presents a novel microfluidic approach for developing large scale screening assays of anticancer compounds on 3D multicellular spheroids. We have developed a microfluidic device with associated protocols that combine the high-throughput characteristics of droplet microfluidics for spheroid formation and aggregation with those of single-phase microfluidics for substance exchange, long term culture and drug perfusion.