Wang, Yijie and Shao, Yu and Ma, Xiaozhou and Zhou, Bini and Faulkner-Jones, Alan and Shu, Wenmiao and Liu, Dongsheng (2017) Constructing tissue-like complex structures using cell-laden DNA hydrogel bricks. ACS Applied Materials and Interfaces. ISSN 1944-8244
Wang_etal_AMI2017_Constructing_tissue_like_complex_structures_using_cell_laden.pdf - Accepted Author Manuscript
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Tissue engineering has long been a challenge because of the difficulty of addressing the requirements that such an engineered tissue must meet. In this paper, we developed a new "brick-to-wall" based on unique properties of DNA supramolecular hydrogels to fabricate three-dimensional (3D) tissuelike structures: different cell types are encapsulated in DNA hydrogel bricks which are then combined to build 3D structures. Signal responsiveness of cells through the DNA gels was evaluated and it was discovered that the gel permits cell migration in 3D. The results demonstrated that this technology is convenient, effective and reliable for cell manipulation, and we believe that it will benefit artificial tissue fabrication and future large-scale production.
|Notes:||This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Applied Materials and Interfaces, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acsami.7b01604.|
|Keywords:||DNA hydrogel, tissue engineering, cell arrangements, cell migration, self-healing, supramolecular, Bioengineering, Biomedical Engineering|
|Subjects:||Technology > Engineering (General). Civil engineering (General) > Bioengineering|
|Department:||Faculty of Engineering > Biomedical Engineering|
|Depositing user:||Pure Administrator|
|Date Deposited:||23 Mar 2017 10:13|
|Last modified:||26 Apr 2017 03:15|