Picture of smart phone in human hand

World leading smartphone and mobile technology research at Strathclyde...

The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by University of Strathclyde researchers, including by Strathclyde researchers from the Department of Computer & Information Sciences involved in researching exciting new applications for mobile and smartphone technology. But the transformative application of mobile technologies is also the focus of research within disciplines as diverse as Electronic & Electrical Engineering, Marketing, Human Resource Management and Biomedical Enginering, among others.

Explore Strathclyde's Open Access research on smartphone technology now...

The mechanical effect of extracorporeal irradiation on bone

Gupta, S. and Cafferky, D. and Cowie, F. and Riches, P. and Anthony, I. and Mahendra, A. (2015) The mechanical effect of extracorporeal irradiation on bone. The Bone and Joint Journal, 97-B (Supp 4). ISSN 2049-4394

[img]
Preview
Text (Gupta-etal-TBJJ-2015-The-mechanical-effect-of-extracorporeal-irradiation-on-bone)
Gupta_etal_TBJJ_2015_The_mechanical_effect_of_extracorporeal_irradiation_on_bone.pdf - Accepted Author Manuscript

Download (869kB) | Preview

Abstract

Extracorporeal irradiation and re-implantation of a bone segment is a technique employed in bone sarcoma surgery for limb salvage in the setting of reasonable bone stock. There is neither consensus nor rationale given for the dosage of irradiation used in previous studies, with values of up to 300Gy applied. We investigated the influence of extracorporeal irradiation on the elastic and viscoelastic properties of bone. Bone specimens were extracted from mature cattle and subdivided into thirteen groups; twelve groups exposed to increasing levels of irradiation and a control group. The specimens, once irradiated, underwent mechanical testing in saline at 37˚C. Mechanical properties were calculated by experimental means which included Young’s Modulus, Poisson’s Ratio, Dissipation Factor, Storage Modulus, Loss Modulus and Dynamic Modulus. These were all obtained for comparison of the irradiated specimens to the control group. We found that the overall effect of increasing irradiation doses up to 300Gy seems to present negligible change, albeit negative, on the behavior of bone. However, the increase in Poisson’s ratio following extracorporeal irradiation treatment was statistically significant. Therefore, it is concluded that the overall mechanical effect of high levels of extracorporeal irradiation (300Gy) is minute, and could be administered to reduce the risk of malignancy recurrence.