Self-assembly of ultra-small micelles from amphiphilic lipopeptoids

Lau, King Hang Aaron and Castelletto, Valeria and Kendall, Thomas and Sefcik, Jan and Hamley, Ian W. and Reza, Mehedi and Ruokolainen, Janne (2017) Self-assembly of ultra-small micelles from amphiphilic lipopeptoids. Chemical Communications, 53 (13). pp. 2178-2181. ISSN 1359-7345 (https://doi.org/10.1039/C6CC09888F)

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Abstract

Poly(N-substituted glycine) “peptoids” constitute a promising class of peptide-mimetic materials. We introduce the self-assembly of lipopeptoids into spherical micelles ca. 5 nm in diameter as well as larger assemblies by varying the peptoid sequence design. Our results point to design rules for the self-assembly of peptoid nanostructures, enabling the creation of stable, ultra-small pep- tidomimetic nanospheres.

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