Picture of smart phone in human hand

World leading smartphone and mobile technology research at Strathclyde...

The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by University of Strathclyde researchers, including by Strathclyde researchers from the Department of Computer & Information Sciences involved in researching exciting new applications for mobile and smartphone technology. But the transformative application of mobile technologies is also the focus of research within disciplines as diverse as Electronic & Electrical Engineering, Marketing, Human Resource Management and Biomedical Enginering, among others.

Explore Strathclyde's Open Access research on smartphone technology now...

New proof-of-concept in viral inactivation : virucidal efficacy of 405 nm light against feline calicivirus as a model for norovirus decontamination

Tomb, Rachael Margaret. and Maclean, Michelle and Coia, John E. and Graham, Elizabeth and McDonald, Michael and Atreya, Chintamani D and MacGregor, Scott J. and Anderson, John G. (2016) New proof-of-concept in viral inactivation : virucidal efficacy of 405 nm light against feline calicivirus as a model for norovirus decontamination. Food and Environmental Virology. ISSN 1867-0342

[img]
Preview
Text (Tomb-etal-FEV2016-New-proof-of-concept-in-viral-inactivation)
Tomb_etal_FEV2016_New_proof_of_concept_in_viral_inactivation.pdf - Final Published Version
License: Creative Commons Attribution 4.0 logo

Download (756kB) | Preview

Abstract

The requirement for novel decontamination technologies for use in hospitals is ever present. One such system uses 405 nm visible light to inactivate microorganisms via ROS generated oxidative damage. Although effective for bacterial and fungal inactivation, little is known about the virucidal effects of 405 nm light. Norovirus (NoV) gastroenteritis outbreaks often occur in the clinical setting and this study was designed to investigate potential inactivation effects of 405 nm light on the NoV surrogate, feline calicivirus (FCV). FCV was exposed to 405 nm light whilst suspended in minimal and organically rich media to establish the virucidal efficacy and the effect biologically-relevant material may play in viral susceptibility. Antiviral activity was successfully demonstrated with a 4 Log10 (99.99%) reduction in infectivity when suspended in minimal media evident after a dose of 2.8 kJ cm-2. FCV exposed in artificial faeces, artificial saliva, blood plasma and other organically-rich media exhibited an equivalent level of inactivation using between 50-85% less dose of the light, indicating enhanced inactivation when the virus is present in organically-rich biologically-relevant media. Further research in this area could aid in the development of 405 nm light technology for effective NoV decontamination within the hospital environment.