Picture of smart phone in human hand

World leading smartphone and mobile technology research at Strathclyde...

The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by University of Strathclyde researchers, including by Strathclyde researchers from the Department of Computer & Information Sciences involved in researching exciting new applications for mobile and smartphone technology. But the transformative application of mobile technologies is also the focus of research within disciplines as diverse as Electronic & Electrical Engineering, Marketing, Human Resource Management and Biomedical Enginering, among others.

Explore Strathclyde's Open Access research on smartphone technology now...

A microfluidics tool for high-throughput, real-time multimodal imaging of nanoparticle-cell interactions

Cunha-Matos, C. A. and Millington, O. M. and Wark, A. W. and Zagnoni, M. (2014) A microfluidics tool for high-throughput, real-time multimodal imaging of nanoparticle-cell interactions. In: 4th European Conference on Microfluidics, Limerick, 10-12 December 2014. Société hydrotechnique de France, Paris. ISBN 9791093567044

[img]
Preview
Text (Cunha-Matos-Micr4ofluidics2014-Microfluidics-tool-for-high-throughput)
Cunha_Matos_Micr4ofluidics2014_Microfluidics_tool_for_high_throughput.pdf - Accepted Author Manuscript

Download (499kB) | Preview

Abstract

The increasing use of nanomaterials for biomedical applications has raised the need for efficient, robust and low-cost high-throughput assessment of nanotoxicity and cell-nanoparticle interactions. Microfluidics provides the tools for high-throughput single-cell functional monitoring, while gold nanorods have unique potential for intracellular tracking and can simultaneously be used as drug carriers. Presented here is a miniaturised platform that integrates these features with a multimodal approach to cell imaging. A microfluidic device allows for trapping of an array of singlecells, followed by the controlled delivery of nanoparticles into the cell array and subsequent real-time multimodal imaging of cellular interactions with functionalised nanoparticles. This system has been successfully used to assess cellnanoparticle interactions at the single-cell level.