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Strathprints serves world leading Open Access research by the University of Strathclyde, including research by the Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), where research centres such as the Industrial Biotechnology Innovation Centre (IBioIC), the Cancer Research UK Formulation Unit, SeaBioTech and the Centre for Biophotonics are based.

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Butylation of phenylacetonitrile in an oscillatory baffled reactor

Wilson, B. and Sherrington, D.C. and Ni, X. (2005) Butylation of phenylacetonitrile in an oscillatory baffled reactor. Industrial and Engineering Chemistry Research, 44 (23). pp. 8663-8670. ISSN 0888-5885

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Abstract

In this paper, we report our investigation of a liquid-liquid phase-transfer catalysis (PTC) of the butylation of phenylacetonitrile in a novel oscillatory baffled reactor. We evaluated the reaction kinetics by looking at the order of the reaction and examined the effect of operating conditions as well as the PTC catalysts on the conversion. The results demonstrated that the conversion is highly dependent upon the operating conditions for all the different PTC catalysts used. Such a dependence provides an effective means of increasing the productivity of the butylation of phenylacetonitrile without involving the design and testing of new catalysts.