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The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs. Strathprints provides access to thousands of Open Access research papers by University of Strathclyde researchers, including those from the School of Psychological Sciences & Health - but also papers by researchers based within the Faculties of Science, Engineering, Humanities & Social Sciences, and from the Strathclyde Business School.

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Molecularly imprinted solid-phase extraction of cocaine metabolites from aqueous samples

Zurutuza, A. and Bayoudh, S. and Cormack, P.A.G. and Dambies, L. and Deere, J. and Bischoff, R. and Sherrington, D.C. (2005) Molecularly imprinted solid-phase extraction of cocaine metabolites from aqueous samples. Analytica Chimica Acta, 542 (1). pp. 14-19. ISSN 0003-2670

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Abstract

Cocaine is a well-known drug of abuse which, when ingested nasally or by smoking, undergoes a number of biotransformation and degradation reactions. In the present work, a synthetic analogue of the cocaine metabolite benzoylecgonine was prepared and used as a template molecule in the preparation of a series of molecularly imprinted polymers (MIPs). Molecularly imprinted solid-phase extraction (MISPE) conditions were established under which benzoylecgonine in aqueous samples could be selectively extracted and quantified at clinically relevant concentrations (mu g/ml). Under optimised MISPE conditions, recoveries of analyte were high (> 70%) and excellent discrimination between imprinted and non-imprinted materials observed.