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Molecularly imprinted solid-phase extraction of cocaine metabolites from aqueous samples

Zurutuza, A. and Bayoudh, S. and Cormack, P.A.G. and Dambies, L. and Deere, J. and Bischoff, R. and Sherrington, D.C. (2005) Molecularly imprinted solid-phase extraction of cocaine metabolites from aqueous samples. Analytica Chimica Acta, 542 (1). pp. 14-19. ISSN 0003-2670

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Abstract

Cocaine is a well-known drug of abuse which, when ingested nasally or by smoking, undergoes a number of biotransformation and degradation reactions. In the present work, a synthetic analogue of the cocaine metabolite benzoylecgonine was prepared and used as a template molecule in the preparation of a series of molecularly imprinted polymers (MIPs). Molecularly imprinted solid-phase extraction (MISPE) conditions were established under which benzoylecgonine in aqueous samples could be selectively extracted and quantified at clinically relevant concentrations (mu g/ml). Under optimised MISPE conditions, recoveries of analyte were high (> 70%) and excellent discrimination between imprinted and non-imprinted materials observed.

Item type: Article
ID code: 533
Keywords: molecularly imprinted polymers, solid-phase extraction, cocaine, cocaine metabolites, benzoylecgonine, Chemistry
Subjects: Science > Chemistry
Department: Faculty of Science > Pure and Applied Chemistry
Unknown Department
Related URLs:
    Depositing user: Mr Derek Boyle
    Date Deposited: 16 Mar 2006
    Last modified: 16 Jul 2013 18:55
    URI: http://strathprints.strath.ac.uk/id/eprint/533

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