Zurutuza, A. and Bayoudh, S. and Cormack, P.A.G. and Dambies, L. and Deere, J. and Bischoff, R. and Sherrington, D.C. (2005) Molecularly imprinted solid-phase extraction of cocaine metabolites from aqueous samples. Analytica Chimica Acta, 542 (1). pp. 14-19. ISSN 0003-2670
Full text not available in this repository. (Request a copy from the Strathclyde author)Abstract
Cocaine is a well-known drug of abuse which, when ingested nasally or by smoking, undergoes a number of biotransformation and degradation reactions. In the present work, a synthetic analogue of the cocaine metabolite benzoylecgonine was prepared and used as a template molecule in the preparation of a series of molecularly imprinted polymers (MIPs). Molecularly imprinted solid-phase extraction (MISPE) conditions were established under which benzoylecgonine in aqueous samples could be selectively extracted and quantified at clinically relevant concentrations (mu g/ml). Under optimised MISPE conditions, recoveries of analyte were high (> 70%) and excellent discrimination between imprinted and non-imprinted materials observed.
| Item type: | Article |
|---|---|
| ID code: | 533 |
| Keywords: | molecularly imprinted polymers, solid-phase extraction, cocaine, cocaine metabolites, benzoylecgonine, Chemistry |
| Subjects: | Science > Chemistry |
| Department: | Faculty of Science > Pure and Applied Chemistry Unknown Department |
| Related URLs: | |
| Depositing user: | Mr Derek Boyle |
| Date Deposited: | 16 Mar 2006 |
| Last modified: | 12 Mar 2012 10:35 |
| URI: | http://strathprints.strath.ac.uk/id/eprint/533 |
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