Zurutuza, A. and Bayoudh, S. and Cormack, P.A.G. and Dambies, L. and Deere, J. and Bischoff, R. and Sherrington, D.C. (2005) Molecularly imprinted solid-phase extraction of cocaine metabolites from aqueous samples. Analytica Chimica Acta, 542 (1). pp. 14-19. ISSN 0003-2670Full text not available in this repository. (Request a copy from the Strathclyde author)
Cocaine is a well-known drug of abuse which, when ingested nasally or by smoking, undergoes a number of biotransformation and degradation reactions. In the present work, a synthetic analogue of the cocaine metabolite benzoylecgonine was prepared and used as a template molecule in the preparation of a series of molecularly imprinted polymers (MIPs). Molecularly imprinted solid-phase extraction (MISPE) conditions were established under which benzoylecgonine in aqueous samples could be selectively extracted and quantified at clinically relevant concentrations (mu g/ml). Under optimised MISPE conditions, recoveries of analyte were high (> 70%) and excellent discrimination between imprinted and non-imprinted materials observed.
|Keywords:||molecularly imprinted polymers, solid-phase extraction, cocaine, cocaine metabolites, benzoylecgonine, Chemistry, Biochemistry, Spectroscopy, Environmental Chemistry, Analytical Chemistry|
|Subjects:||Science > Chemistry|
|Department:||Faculty of Science > Pure and Applied Chemistry|
|Depositing user:||Mr Derek Boyle|
|Date Deposited:||16 Mar 2006|
|Last modified:||03 Feb 2017 03:06|