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The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by University of Strathclyde researchers, including by researchers from the Department of Computer & Information Sciences involved in mathematically structured programming, similarity and metric search, computer security, software systems, combinatronics and digital health.

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Development of a droplet microfluidic assay for radiotherapy treatment of multicellular spheroids

McMillan, Kay and Boyd, Marie["lib/metafield:join_name.last" not defined]Zagnoni, Michele (2014) Development of a droplet microfluidic assay for radiotherapy treatment of multicellular spheroids. In: MicroTAS 2014. CBM Society, San Diego, CA., pp. 923-925. ISBN 9780979806476

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Abstract

In this study, we report the development of a droplet microfluidic assay for the formation and radiotherapy treatment of multicellular spheroids. Glioma cells formed multicellular spheroids following their encapsulation within biocompatible medium-in-fluorinated oil (M/O) droplets with a non-adherent surfactant interface. Our studies identified that the ratio of volume-of-medium to number-of-cells and the refreshment of medium are important parameters for healthy spheroid growth within M/O droplets. In addition, a protocol was validated to extract radiotherapy dose responses from the spheroids based on their size variation via brightfield microscopy.