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A new molecularly imprinted polymer for the selective extraction of naproxen from urine samples by solid-phase extraction

Caro, E. and Marce, R.M. and Cormack, P.A.G. and Sherrington, D.C. and Borrull, F. (2004) A new molecularly imprinted polymer for the selective extraction of naproxen from urine samples by solid-phase extraction. Journal of Chromatography B, 813 (1-2). pp. 137-143. ISSN 1570-0232

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Abstract

A non-covalent molecularly imprinted polymer (MIP) was synthesised using naproxen (a non-steroidal, anti-inflammatory drug (NSAID)) as a template molecule. The NIT was chromatographically evaluated to confirm the imprinting effect, and was then applied as a selective sorbent in solid-phase extraction (SPE) to selectively extract naproxen. After this study, the NIT was used to extract naproxen from urine samples; it was demonstrated that by applying a selective washing step with acetonitrile (ACN) the compounds in the sample that were structurally related to naproxen could be eliminated.