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The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by Strathclyde researchers, including by researchers from the Physical Activity for Health Group based within the School of Psychological Sciences & Health. Research here seeks to better understand how and why physical activity improves health, gain a better understanding of the amount, intensity, and type of physical activity needed for health benefits, and evaluate the effect of interventions to promote physical activity.

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A new molecularly imprinted polymer for the selective extraction of naproxen from urine samples by solid-phase extraction

Caro, E. and Marce, R.M. and Cormack, P.A.G. and Sherrington, D.C. and Borrull, F. (2004) A new molecularly imprinted polymer for the selective extraction of naproxen from urine samples by solid-phase extraction. Journal of Chromatography B, 813 (1-2). pp. 137-143. ISSN 1570-0232

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Abstract

A non-covalent molecularly imprinted polymer (MIP) was synthesised using naproxen (a non-steroidal, anti-inflammatory drug (NSAID)) as a template molecule. The NIT was chromatographically evaluated to confirm the imprinting effect, and was then applied as a selective sorbent in solid-phase extraction (SPE) to selectively extract naproxen. After this study, the NIT was used to extract naproxen from urine samples; it was demonstrated that by applying a selective washing step with acetonitrile (ACN) the compounds in the sample that were structurally related to naproxen could be eliminated.