Expanded applicability of iridum(I) NHC-phosphine catalysts in hydrogen isotope exchange processes with pharmaceutically-relevant heterocycles

Atzrodt, Jens and Derdau, Volker and Kerr, William J. and Reid, Marc and Rojahn, Patrick and Weck, Remo (2015) Expanded applicability of iridum(I) NHC-phosphine catalysts in hydrogen isotope exchange processes with pharmaceutically-relevant heterocycles. Tetrahedron, 71 (13). pp. 1924-1929. ISSN 0040-4020 (https://doi.org/10.1016/j.tet.2015.02.029)

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Abstract

An assessment of emerging C-H activation catalysts of the type [(COD)Ir(IMes)(PR3)]PF6 in the deuteration of N-heterocycles is divulged. Substrate scope, competition experiments, and labelling of drug type molecules have revealed PR3 = PPh3 provides a broadly more applicable and widely effective catalyst system compared to other available complexes in the present series

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