A modular synthesis of functionalised phenols enabled by controlled boron speciation

Molloy, John J. and Law, Robert P. and Fyfe, James W.B. and Seath, Ciaran P. and Hirst, David J. and Watson, Allan J.B. (2015) A modular synthesis of functionalised phenols enabled by controlled boron speciation. Organic and Biomolecular Chemistry. ISSN 1477-0520 (https://doi.org/10.1039/C5OB00078E)

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Abstract

A modular synthesis of functionalised biaryl phenols from two boronic acid derivatives has been developed via one-pot Suzuki-Miyaura cross-coupling, chemoselective control of boron solution speciation to generate a reactive boronic ester in situ, and oxidation. The utility of this method has been further demonstrated by application in the synthesis of drug molecules and components of organic electronics, as well as within iterative cross-coupling.

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• Item metadata

  Item type:	Article
  ID code:	51326
  Dates:	Date Event 21 January 2015 Published 21 January 2015 Published Online 21 January 2015 Accepted
  Subjects:	Science > Chemistry
  Department:	Faculty of Science > Pure and Applied Chemistry
  Depositing user:	Pure Administrator
  Date deposited:	28 Jan 2015 14:38
  Last modified:	18 Apr 2024 00:16
  URI:	https://strathprints.strath.ac.uk/id/eprint/51326