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World class computing and information science research at Strathclyde...

The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by University of Strathclyde researchers, including by researchers from the Department of Computer & Information Sciences involved in mathematically structured programming, similarity and metric search, computer security, software systems, combinatronics and digital health.

The Department also includes the iSchool Research Group, which performs leading research into socio-technical phenomena and topics such as information retrieval and information seeking behaviour.


Inactivation of microorganisms within collagen gel biomatrices using pulsed electric field treatment

Griffiths, Sarah and Maclean, Michelle and Anderson, John G. and Macgregor, Scott J. and Grant, H. Mary (2012) Inactivation of microorganisms within collagen gel biomatrices using pulsed electric field treatment. Journal of Materials Science: Materials in Medicine, 23 (2). pp. 507-515. ISSN 0957-4530

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Pulsed electric field (PEF) treatment was examined as a potential decontamination method for tissue engineering biomatrices by determining the susceptibility of a range of microorganisms whilst within a collagen gel. High intensity pulsed electric fields were applied to collagen gel biomatrices containing either Escherichia coli, Pseudomonas aeruginosa, Staphylococcus epidermidis, Candida albicans, Saccharomyces cerevisiae or the spores of Aspergillus niger. The results established varying degrees of microbial PEF susceptibility. When high initial cell densities (106–107 CFU ml−1) were PEF treated with 100 pulses at 45 kV cm−1, the greatest log reduction was achieved with S. cerevisiae (~6.5 log10 CFU ml−1) and the lowest reduction achieved with S. epidermidis (~0.5 log10 CFU ml−1). The results demonstrate that inactivation is influenced by the intrinsic properties of the microorganism treated. Further investigations are required to optimise the microbial inactivation kinetics associated with PEF treatment of collagen gel biomatrices.