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Effect of cultured rat primary hepatocytes on the mechanical properties of collagen gel matrices

Agbekoh, Peter E. and Henderson, Catherine and Riches, Philip E. and Grant, M. Helen (2014) Effect of cultured rat primary hepatocytes on the mechanical properties of collagen gel matrices. European Cells and Materials, 28 (S.4). p. 77. ISSN 1473-2262

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Abstract

Collagen gels are widely used as matrices for in vitro cell culture and also for a variety of tissue engineering applications. The mechanical properties of matrices have been shown to be important parameters which greatly influence cell behaviour. For successful support of long term cell growth and function, it is important for matrices to retain their mechanical integrity during the period of use. The presence of cells has been shown to alter matrix properties. The aim of this study was to investigate the effect of seeding primary hepatocytes on the mechanical properties of collagen hydrogel matrices.