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The effects of decellularisation on the mechanical properties of bone

Mohamad, Mohd Riduan and Riches, Philip and Grant, M. Helen (2014) The effects of decellularisation on the mechanical properties of bone. European Cells and Materials, 28 (S.4). p. 72. ISSN 1473-2262

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Abstract

Bone defects as a result of trauma and physiological and pathological bone resorption represent a major challenge and have become a worldwide health issue. Regenerative medicine strategies involving decellularised extracellular matrix scaffolds are developing very fast. This project aims to demonstrate and establish decellularisation protocols to make donor bone scaffold, which could be used to repair bone defects in recipient patients and to determine whether the decellularisation process alters the mechanical properties of the bone scaffold.