Pharmacokinetic optimisation of novel indole-2-carboxamide cannabinoid CB1 antagonists

Cowley, Phillip M and Baker, James and Buchanan, Kirsteen I and Carlyle, Ian and Clark, John K and Clarkson, Thomas R and Deehan, Maureen and Edwards, Darren and Kiyoi, Yasuko and Martin, Iain and Osbourn, Dawn and Walker, Glenn and Ward, Nick and Wishart, Grant (2011) Pharmacokinetic optimisation of novel indole-2-carboxamide cannabinoid CB1 antagonists. Bioorganic and Medicinal Chemistry Letters, 21 (7). pp. 2034-2039. ISSN 0960-894X (https://doi.org/10.1016/j.bmcl.2011.02.019)

Abstract

The pharmacokinetic based optimisation of a novel series of indole-2-carboxamide antagonists of the cannabinoid CB(1) receptor is disclosed. Compound 24 was found to be a highly potent and selective cannabinoid CB(1) antagonist with high predicted human oral bioavailability.

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• Item metadata

  Item type:	Article
  ID code:	49473
  Dates:	Date Event 1 April 2011 Published
  Subjects:	Medicine > Other systems of medicine Science > Chemistry > Physical and theoretical chemistry
  Department:	Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
  Depositing user:	Pure Administrator
  Date deposited:	01 Oct 2014 15:07
  Last modified:	08 Apr 2024 21:41
  Related URLs:	Journal or Publication
  URI:	https://strathprints.strath.ac.uk/id/eprint/49473