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Model development and optimal experimental design of a kinetically controlled synthesis system

Yue, Hong and Halling, Peter and Yu, Hui (2013) Model development and optimal experimental design of a kinetically controlled synthesis system. In: International Symposium on Computer Applications in Biotechnology (CAB2013), 2013-12-16 - 2013-12-18.

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A mathematical model has been developed for an enzymatic process with kinetically controlled synthesis. Model reduction and detailed system analysis have been undertaken to examine the main properties of this enzyme reaction system. Optimal experimental design (OED) is developed to obtain the experimental conditions that will generate the most informative measurement data for parameter estimation. Both single-input and multiple-inputs optimisation strategies have been investigated to determine the best intensity levels of control inputs. The results demonstrate that parameter estimation quality can be improved through proper model-based experimental design.