Molar efficiency : a useful metric to gauge relative reaction efficiency in discovery medicinal chemistry

McGonagle, Fiona I. and Sneddon, Helen F. and Jamieson, Craig and Watson, Allan (2014) Molar efficiency : a useful metric to gauge relative reaction efficiency in discovery medicinal chemistry. ACS Sustainable Chemistry and Engineering, 2 (3). pp. 523-532. ISSN 2168-0485 (https://doi.org/10.1021/sc4004532)

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Abstract

The concept of molar efficiency is introduced as a new metric to enable assessment of reaction efficiency in discovery medicinal chemistry. Calculations from molar units enable cross-comparison of the broad range of transformations employed in discovery-phase medicinal chemistry research and is proposed to facilitate identification of more sustainable synthetic transformations.

ORCID iDs

McGonagle, Fiona I., Sneddon, Helen F., Jamieson, Craig ORCID logoORCID: https://orcid.org/0000-0002-6567-8272 and Watson, Allan;