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Micromachined scaffolds as primers for cartilage growth

Angeli, F. and Connolly, P. and Uttamchandani, D.G. (2006) Micromachined scaffolds as primers for cartilage growth. Micro and Nano Letters, 1 (2). pp. 66-70. ISSN 1750-0443

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Abstract

Research on the growth and monitoring of cartilage cells in a controlled microstructured environment is important because of the consideration of how the microenvironment affects the cells involved in cartilage regeneration has been neglected to date. An experimental realisation has been demonstrated of biocompatible microstructured surfaces of controlled topography, which have been formed in biocompatible polyimide (Kapton) and in synthetic bioresorbable, epsilon-polycaprolactone (PCL). Bovine cartilage cell growth has been achieved in vitro on the microstructured surfaces and the retention of chondrocytic morphology has been investigated. The results demonstrate that PCL and Kapton microgrooved surfaces can act as primers for cartilage regeneration and repair in vitro or potentially in vivo, by retaining chondrocytic phenotype and enhancing cartilage formation.

Item type: Article
ID code: 4798
Keywords: bioengineering, microstructured environment, cartilage, micro-biology, Bioengineering, Biomedical Engineering, Bioengineering, Materials Science(all), Condensed Matter Physics
Subjects: Technology > Engineering (General). Civil engineering (General) > Bioengineering
Department: Faculty of Engineering > Bioengineering
Unknown Department
Faculty of Engineering > Electronic and Electrical Engineering
Related URLs:
    Depositing user: Strathprints Administrator
    Date Deposited: 22 Nov 2007
    Last modified: 04 Sep 2014 16:54
    URI: http://strathprints.strath.ac.uk/id/eprint/4798

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