de Boer, T. and Mol, R. and de Zeeuw, R.A. and de Jong, G.J. and Sherrington, D.C. and Cormack, P.A.G. and Ensing, K. (2002) Spherical molecularly imprinted polymer particles: A promising tool for molecular recognition in capillary electrokinetic separations. Electrophoresis, 23 (9). pp. 1296-1300. ISSN 0173-0835Full text not available in this repository. (Request a copy from the Strathclyde author)
Spherical molecularly imprinted polymer particles obtained via precipitation polymerization, were introduced as a pseudostationary phase in capillary electrophoresis (CE) to study molecular recognition. Analyses were performed via a partial filling technique using (+)-ephedrine-imprinted microspheres (100-200 nm) which were polymerized from methacrylic acid and 1,1,1-Tris(hydroxymethyl)propanetrimethacrylate using acetonitrile as the solvent. The influence of pH and the modifier content on the separation was investigated. A 0.1 % w/v suspension in an aqueous 10 mm phosphate buffer (pH 2.5 with 40% acetonitrile) was hydrodynamically injected into the CE system (80% of the effective capillary length) and led to full baseline separation of racemic ephedrine within 10 min.
|Keywords:||capillary electrokinetic chromatography, molecular recognition, molecularly imprinted polymers, Chemistry, Biochemistry, Clinical Biochemistry|
|Subjects:||Science > Chemistry|
|Department:||Faculty of Science > Pure and Applied Chemistry|
|Depositing user:||Mr Derek Boyle|
|Date Deposited:||09 Mar 2006|
|Last modified:||06 Jan 2017 03:15|