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Optimisation of a lipid based oral delivery system containing A/Panama influenza haemagglutinin

Mann, J.F.S. and Ferro, V.A. and Mullen, A. and Tetley, L. and Mullen, M. and Carter, K.C. and Alexander, J. and Stimson, W.H. (2004) Optimisation of a lipid based oral delivery system containing A/Panama influenza haemagglutinin. Vaccine, 22 (19). pp. 2425-2429. ISSN 0264-410X

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Abstract

Vaccine antigens administered by the oral route are often degraded by gastric secretions during gastrointestinal transit. This necessitates larger and more frequent doses of antigen for vaccination. A delivery system, which overcomes this, is a lipid vesicle containing bile salts (bilosome), which prevents antigen degradation and enhances mucosal penetration. The effect of bilosome formulation modification on vaccine transit efficacy across the mucosa was determined. Specific antibody levels were assessed by end-point titre ELISA and the subclasses determined. Significant IgG1 titres were induced when the protein loading was doubled from 15 to 30 μg (P=0.009) and was equivalent to antigen administration by the subcutaneous route. No IgG2a was induced, indicating the generation of a TH2 response. Significant mucosal IgA levels were also observed with this treatment group (P=0.05).