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An oligofluorene truxene based distributed feedback laser for biosensing applications

Haughey, Anne-Marie and Guilhabert, Benoit and Kanibolotsky, Alexander L and Skabara, Peter J and Dawson, Martin D and Burley, Glenn A and Laurand, Nicolas (2014) An oligofluorene truxene based distributed feedback laser for biosensing applications. Biosensors and Bioelectronics, 54. pp. 679-686. ISSN 0956-5663

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Abstract

The first example of an all-organic oligofluorene truxene based distributed feedback laser for the detection of a specific protein–small molecule interaction is reported. The protein avidin was detected down to View the MathML source1μgmL−1 using our biotin-labelled biosensor platform. This interaction was both selective and reversible when biotin was replaced with desthiobiotin. Avidin detection was not perturbed by Bovine Serum Albumin up to View the MathML source50,000μgmL−1. Our biosensor offers a new detection platform that is both highly sensitive, modular and potentially re-usable.