Exceptionally strong intermolecular association in hydrophobic DNA minor groove binders and their potential therapeutic consequences

Parkinson, John A and Scott, Fraser J and Suckling, Colin J and Wilson, Gail (2013) Exceptionally strong intermolecular association in hydrophobic DNA minor groove binders and their potential therapeutic consequences. MedChemComm, 4 (7). pp. 1105-1108. (https://doi.org/10.1039/C3MD00071K)

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Abstract

An antibacterial DNA minor groove binder is shown by NOE experiments to self-associate in aqueous solution at temperatures up to 80 C in an anti-parallel, head-to-tail orientation as found in binding to duplex DNA oligomers.

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• Item metadata

  Item type:	Article
  ID code:	44425
  Dates:	Date Event 2013 Published 20 May 2013 Published Online
  Subjects:	Science > Chemistry
  Department:	Faculty of Science > Pure and Applied Chemistry
  Depositing user:	Pure Administrator
  Date deposited:	31 Jul 2013 15:24
  Last modified:	23 Apr 2024 00:10
  Related URLs:	Scopus publication
  URI:	https://strathprints.strath.ac.uk/id/eprint/44425